O-Acetyl-GD2 as a Therapeutic Target for Breast Cancer Stem Cells

Researchers from Taiwan and California, directed by Pr. Alice Yu, have published new data showing that OAcGD2 is a novel marker for breast cancer stem cells, the rare subset of tumor cells that drives tumor progression and disease recurrence .

Researchers have used patient-derived tumors grafted in NOD/SCID mice to demonstrated that the treatment with anti-OAcGD2 antibody, developed by OGD2 Pharma, may have superior anticancer efficacy in breast cancer by targeting cancer stem cells, thereby reducing metastasis and recurrence of cancer.

Cheng JY, Hung JT, Lin J, Lo FY, Huang JR, Chiou SP, Wang YH, Lin RJ, Wu JC, Yu J, Yu AL. O-Acetyl-GD2 as a Therapeutic Target for Breast Cancer Stem Cells.

Front Immunol. 2022 Jan 3;12:791551. https://pubmed.ncbi.nlm.nih.gov/35046949/

OGD2 Pharma publishes new data on glioblastoma antibody therapy

27 May 2016 : In our efforts to fight brain cancer we are proud to annonce the publication of new data supporting the therapeutic activity of our antibody in brain tumors. Research was  performed in collaboration with Centre de Recherche Contre le Cancer de Nantes Angers (CRCNA) and supported by Agence Nationale de la Recherche (ANR).

Fleurence 2016 Oncotarget – Targeting GBM

Abstract: There are still unmet medical needs in the treatment of glioblastoma, the most common and the most aggressive glioma of all brain tumors. Here, we found that O-acetyl GD2 is expressed in surgically resected human glioblastoma tissue. In addition, we demonstrated that 8B6 monoclonal antibody specific for O-acetylated GD2 could effectively inhibit glioblastoma cell proliferation in vitro and in vivo. Taken together, these results indicate that O-acetylated GD2 represents a novel antigen for immunotherapeutic-based treatment of high-grade gliomas.

Anti-O-acetylated-GD2 monoclonal antibody designated as an orphan drug for the treatment of neuroblastoma by EMA

On 2 March 2015 the European Medicines Agency published its public summary of opinion on orphan designation for OGD2 Pharma chimeric monoclonal antibody to O-acetyl-GD2 antigen for the treatment of neuroblastoma granted by the European Commission on 15 January 2015 (EU/3/14/1416).

“The sponsor has provided sufficient information to show that chimeric monoclonal antibody to O-acetyl-GD2 antigen might be of significant benefit for patients with neuroblastoma because it works in a different way to currently authorised treatments by specifically targeting tumour tissue. In addition, early studies in experimental models showed improved anti-tumour activity. These assumptions will need to be confirmed at the time of marketing authorisation, in order to maintain the orphan status.

Chimeric monoclonal antibody to O-acetyl-GD2 antigen is a monoclonal antibody (a type of protein) that has been designed to recognise and attach to a specific structure (an antigen) called O-acetyl-GD2. O-acetyl-GD2 is a substance that is present in high amounts on the surface of neuroblastoma cells, but not normal cells. When the medicine attaches to the neuroblastoma cells, it marks them out as a target for the body’s immune system, which is then expected to attack the cancer cells and thereby reverse or slow down the progression of the disease.”

“Neuroblastoma is a cancer of nerve cells which is usually seen as a lump in the abdomen or around the spine. Symptoms may include weakness, bone pain, loss of appetite and fever. Neuroblastoma is the most common solid tumour outside the brain in children. In many cases it is present at birth but is diagnosed later when the cancer has spread to other parts of the body and the child begins to show symptoms of the disease. Neuroblastoma is a long-term debilitating and life-threatening disease that is associated with poor long-term survival.

At the time of designation, neuroblastoma affected approximately 1.1 in 10,000 people in the
European Union (EU). This was equivalent to a total of around 56,000 people*, and is below the ceiling for orphan designation, which is 5 people in 10,000. This is based on the information provided by the sponsor and the knowledge of the Committee for Orphan Medicinal Products (COMP).

At the time of designation, several medicines were authorised in the EU for the treatment of
neuroblastoma. Treatments for neuroblastoma included surgery, chemotherapy (medicines to treat cancer) and radiotherapy (treatment with radiation).”

For more information: European Medicine Agency

OGD2 Pharma incorporated with the mission to improve anti-GD2 immunotherapy of cancer

OGD2 Pharma SAS has been incorporated in Nantes on 28 October 2014 with the mission to research, develop and commercialize with pharma partners innovative cancer immunotherapies against the O-acetylated form of the GD2 ganglioside (OAcGD2).

As its first cousin GD2, the OAcGD2 glycolipid is highly expressed at the cell membrane of orphan pediatric cancers (e.g. neuroblastoma), adult cancers (e.g. glioma, sarcoma, melanoma), and at the surface of cancer stem cells (e.g. in breast cancers) that are thought to be the chemo- and radio-resistant cells initiating cancer recurrences.

Anti-GD2 immunotherapies – monoclonal antibodies, immunocytokines, chimeric antigen receptor (CAR cells) – have been shown highly promising, but unfortunately also quite toxic (dose-limiting pain and neuropathies) since GD2 is also expressed on the surface of normal nerves and brain cells.

By contrast to GD2, OAcGD2 is not expressed on normal nerves and brain cells. Thus, with anti-OAcGD2 therapies, toxicity to the nervous system is not observed in animal models and is not expected in human.

Thanks to this exquisite tumor-specificity of the OAcGD2 antigen, OGD2 Pharma develops safe and efficacious cancer immunotherapies to meet the medical needs of pediatric and adult cancer patients in both orphan and major indications.